Molecular Testing Options

Targeted Therapy for Hepatocellular CarcinomaBookmark

This scientific review paper published in the journal Signal Transduction and Targeted Therapy discusses recent research into newer medications that show promise as targeted therapies for some cases of primary hepatocellular carcinoma, following molecular testing.

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Léon C. van Kempen, PhD, on a Successful Molecular Tumor Board in NSCLCBookmark

This article from MedPage Today discusses recent study findings demonstrating that patients with complex cases of non-small cell lung cancer can benefit from the insights of a molecular tumor board.

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Molecular Profiling in Metastatic Colorectal CancerBookmark

Article from the academic journal Oncology, curated by Contributing Editor George Lundberg, MD, who notes:

Molecular testing is essential to guide effective treatment in metastatic colorectal cancer. This academic review article provides a good overview of the topic.

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FDA OKs Liquid Biopsy to Identify EGFR-Positive Lung CancerBookmark

Article from MedPage Today curated by Editor in Chief George Lundberg, MD, who notes: 

The U.S. Food and Drug Administration (FDA) has approved a liquid biopsy test (a type of biopsy that uses a blood draw instead of surgery) for detecting whether patients have EGFR mutations in their metastatic lung tumors, which could help guide treatment options.

Go to full article published by MedPage Today.

If you’re wondering whether this story applies to your own cancer case or a loved one’s, we invite you to get support from Cancer Commons.

Pembrolizumab Provides Long-Term Benefit in Melanoma, Regardless of BRAF+ Status or Prior Targeted TherapyBookmark

Article from OncLive curated by Editor in Chief George Lundberg, MD, who notes: 

A new study shows that the drug pembrolizomab significantly prolongs survival in patients with metastatic melanoma, regardless of whether their tumors have mutations in the BRAF gene or if they’ve had prior treatment with targeted therapy.

Go to full article published by OncLive.

If you’re wondering whether this story applies to your own cancer case or a loved one’s, we invite you to get support from Cancer Commons.

The Central Nervous System Tumor Methylation Classifier Changes Neuro-Oncology Practice for Challenging Brain Tumor Diagnoses and Directly Impacts Patient CareBookmark

Academic research paper from Clinical Epigenetics curated by Editor in Chief George Lundberg, MD, who notes: 

Brain tumor treatment decisions may be improved by integrating methylation-based tumor classification into the diagnosis process. Methylation refers to specific chemical features of tumor DNA that may impact how well different treatments might work.

Go to full academic research paper from Clinical Epigenetics.

If you’re wondering whether this story applies to your own cancer case or a loved one’s, we invite you to get support from Cancer Commons.

Brain Tumor Liquid Biopsy Detects DNA Methylation ProfilesBookmark

Article from Clinical OMICs curated by Editor in Chief George Lundberg, MD, who notes: 

Researchers have recently demonstrated a noninvasive way to diagnose and classify brain tumors using a blood test. This promising “liquid biopsy” method detects cell-free tumor DNA in the blood and analyzes its chemical features—specifically, its “methylation patterns”—with high sensitivity and accuracy. Such a test could help guide treatment decisions.

Go to full article published by Clinical OMICs.

If you’re wondering whether this story applies to your own cancer case or a loved one’s, we invite you to get support from Cancer Commons.

Adult H3K27M-Mutant Diffuse Midline Glioma with Gliomatosis Cerebri Growth Pattern: Case Report and Review of the LiteratureBookmark

Research paper from the International Journal of Surgery Case Reports curated by Editor in Chief George Lundberg, MD, who notes: 

We present here an open-access case report and literature review of a patient with the H2K27M-mutant variant of diffuse midline glioma.

Go to full paper published in the International Journal of Surgery Case Reports.

If you’re wondering whether this story applies to your own cancer case or a loved one’s, we invite you to get support from Cancer Commons.

Molecularly Guided Therapy in Pancreatic Cancer: Untapped Potential and the ‘Bright Future’ AheadBookmark

Article from Medscape curated by Editor in Chief George Lundberg, MD, who notes: 

Molecularly matched treatment for pancreatic cancer may extend life for some patients.

Go to full article published by Medscape.

If you’re wondering whether this story applies to your own cancer case or a loved one’s, we invite you to get support from Cancer Commons.

Predicting Prognosis in GlioblastomaBookmark

Article from The Pathologist curated by Editor in Chief George Lundberg, MD, who notes: 

Liquid biopsy shows surprising apparent prognostic value in glioblastoma multiforme (GBM).

Go to full article published by The Pathologist.

If you’re wondering whether this story applies to your own cancer case or a loved one’s, we invite you to get support from Cancer Commons.