• January 11, 2022  

    Cardiometabolic Medications That Inhibit mTOR Might Help Prevent or Treat Cancer

    With: William H. Bestermann Jr, MD

    Many people believe that cancer is a metabolic disease. A biological process known as the mTOR pathway controls cellular metabolism by way of central signaling, and it is involved in tumor growth. Here, our Curious Dr. George asks William H. Bestermann Jr, MD, an internal medicine doctor, how medications that target the protein mTOR and its associated pathway could prevent or treat cancer. Dr.… Read more »

  • November 22, 2021  

    Using Virtual Trials to Screen for Potential Glioblastoma Therapies

    With: Al Musella, DPM

    The existing drug development system “has failed miserably” for people with glioblastoma brain tumors, according to Al Musella, DPM, President of the Musella Foundation for Brain Tumor Research & Information, Inc. In partnership with Cancer Commons, his organization’s Brain Tumor Virtual Trial aims to speed discovery of promising new glioblastoma treatments. Curious Dr. George: How might your Virtual Trial approach speed the process toward… Read more »

  • November 10, 2021  

    New Targeted Treatment Options for Non-Small Cell Lung Cancer in 2021

    Emma Shtivelman, PhD

    Chemotherapy was once the only treatment available for metastatic or advanced non-small lung cancer (NSCLC). But the situation has changed dramatically in recent years. NSCLC may harbor mutations that drive cancer development, and many of these mutations can be targeted with precision drugs that inhibit specific mutant proteins. Targeted drugs not only often prolong survival of patients compared to chemotherapy, but they also improve… Read more »

  • October 20, 2021  

    How an Expert Would Manage His Wife’s Metastatic Breast Cancer

    With: Richard B. Schwab, MD

    For most people with breast cancer, a lump is the first sign that leads to diagnosis. But some cases are not detected until after spread has already occurred. Here, our Curious Dr. George asks Richard B. Schwab, MD, how he would approach such a case if his own wife were the patient. Dr. Schwab is Professor of Medicine in the Division of Hematology/Oncology and… Read more »

  • October 18, 2021  

    Novel Car-T Shows ‘Promising Early Signs of Clinical Efficacy’ for Diffuse Midline Gliomas Bookmark

    George Lundberg, MD

    Healio outlines results from a Stanford University study suggesting that a type of treatment known as CAR T-cell therapy is promising for children with diffuse midline gliomas. The treatment is still in an early phase of testing in humans.

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  • October 18, 2021  

    Stereotactic Radiotherapy for Pancreatic Cancer: A Single-Institution Experience Bookmark

    George Lundberg, MD

    This scientific manuscript from Cureus reports results from a Toronto cancer center suggesting that stereotactic radiotherapy offers another option for palliative treatment of inoperable pancreatic cancer.

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  • October 18, 2021  

    Regularly Updated List of Recent FDA Approvals for Liver Cancer Bookmark

    George Lundberg, MD

    This resource from the U.S. Food and Drug Administration (FDA) lists recent drug approval announcements for liver cancer and related conditions. It also provides link to information about additional approvals that may not be announced.

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  • August 16, 2021  

    The Latest in Melanoma Treatment: A Guest Perspective

    With: Ryan Sullivan, MD

    What’s new in melanoma treatment? Our chief scientist Emma Shtivelman, PhD, recently outlined the latest options. Here, our Curious Dr. George invites a response from Ryan Sullivan, MD, Associate Director of the Melanoma Program at Massachusetts General Hospital Cancer Center and Associate Professor at Harvard Medical School. Curious Dr. George: As a melanoma expert, what are your thoughts on the treatments outlined in our… Read more »

  • August 11, 2021  

    Researching More Second-Line Options for Pancreatic Cancer Bookmark

    Lola Rahib, PhD

    Article from Let’s Win! Pancreatic Cancer: A clinical trial is testing a promising treatment called eryaspase to see how well it performs as a second-line option for metastatic pancreatic cancer.

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  • July 28, 2021  

    New Chronic Lymphocytic Leukemia Treatments 2021 Bookmark

    George Lundberg, MD

    TheSocialMedwork outlines several new drugs for treating chronic lymphocytic leukemia, including Brukinsa (zanubrutinib).

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