• September 16, 2024  

    How an Expert Would Manage His Own Advanced Bladder Cancer: An Update

    With: Daniel E.C. Fein, MD

    When facing a frightening new cancer diagnosis, some people ask their doctors, “What would you do if you were me?” Here, our Curious Dr. George asks Daniel E.C. Fein, MD, how he would handle his own case of advanced bladder cancer. Dr. Fein is a genitourinary oncologist at Beth Israel Deaconess Medical Center (BIDMC) in Boston, MA, as well as an Instructor in Medicine… Read more »

  • August 6, 2024  

    How an Expert Would Manage His Wife’s Metastatic Breast Cancer: An Update

    With: Richard B. Schwab, MD

    For most people with breast cancer, a lump is the first sign that leads to diagnosis. But some cases are not detected until after spread has already occurred. Here, our Curious Dr. George asks Richard B. Schwab, MD, how he would approach such a case if his own wife were the patient. Dr. Schwab is Senior Medical Director at Genentech Product Development Oncology. (Note:… Read more »

  • August 2, 2024  

    How an Expert Would Manage Her Own Advanced Colorectal Cancer: An Update

    With: Christina Wu, MD

    When facing a new cancer diagnosis, some people ask their doctors, “What would you do if you were me?” Here, our Curious Dr. George asks oncologist Christina Wu, MD, how she would handle her own diagnosis of metastatic colorectal cancer. Dr. Wu is a Professor of Medicine at the Mayo Clinic in Phoenix, Arizona. (Note: This piece originally appeared in 2020; now, Dr. Wu… Read more »

  • July 26, 2024  

    How an Expert Would Treat His Own Advanced Lung Cancer: An Update

    With: Jack West, MD

    A new cancer diagnosis is overwhelming. Patients often ask their doctors, “What would you do if you were me?” Here, our Curious Dr. George asks lung cancer expert Howard (Jack) West, MD, FASCO, how he would handle his own diagnosis of advanced lung cancer. Dr. West is a Princeton- and Harvard-educated oncologist with additional training and experience in Boston and Seattle focusing on lung… Read more »

  • July 22, 2024  

    How an Expert Would Manage His Own Advanced Prostate Cancer: An Update

    With: Marc B. Garnick, MD

    When facing a new cancer diagnosis, some people ask their doctors, “What would you do if you were me?” Here, our Curious Dr. George asks Marc B. Garnick, MD, how he would handle his own advanced prostate cancer. Dr. Garnick is the Gorman Brothers Professor of Medicine at Harvard Medical School (HMS) and Beth Israel Deaconess Medical Center in Boston, MA. He is also… Read more »

  • July 11, 2024  

    The Personalized Power of the “N-of-1” Approach

    With: Glenn Sabin

    Randomized, controlled clinical trials with a large N—number of participants—are the recognized “gold standard” of evidence-based medicine. Even so, the results of large-N trials can only reveal population averages, and are not predictive of any individual’s response to a given treatment. On the other hand, one can consider every patient with cancer as the sole participant in their own clinical trial with an Nof1, even if the trial is not… Read more »

  • May 30, 2024  

    How Would an Expert Manage His Own Acute Myelogenous Leukemia: an Update

    With: Adam Asch, MD

    When facing a frightening new cancer diagnosis, some people ask their doctors, “What would you do if you were me?” Previously, our Curious Dr. George asked leukemia expert Adam Asch, MD, how he would handle his own hypothetical case of acute myelogenous leukemia (AML). Now, Dr. Asch provides an updated answer, highlighting the new option of clinical trials offering novel targeted therapies for some… Read more »

  • May 27, 2024  

    How Would an Expert Manage His Own Advanced Hodgkin Lymphoma: an Update

    With: Kevin Knopf, MD, MPH

    When facing a frightening new cancer diagnosis, some people ask their doctors, “What would you do if you were me?” Here, our Curious Dr. George asks oncologist Kevin Knopf, MD, how he would handle his own advanced Hodgkin lymphoma. Curious Dr. George: Please consider this hypothetical scenario—as a very busy practicing clinical oncologist during the COVID-19 pandemic, you were not paying much attention to… Read more »

  • May 16, 2024  

    SAGE Oncotest: Entering the Next Generation of Tailored Cancer Treatment

    With: Chris Apfel, MD, PhD, MBA

    For people with recurring or drug-resistant cancer, choosing the best-possible next treatment can pose a huge challenge. Our Curious Dr. George asks Chris Apfel, MD, PhD, MBA—Founder, CEO, and Board Chair of SageMedic Corp.—about his company’s solution for many of these patients. Curious Dr. George: Despite the application of curative surgical, radiation, and systemic treatments, cancer remains the “emperor of all maladies” with 600,000… Read more »

  • April 2, 2024  

    Treating Pancreatic Cancer: Could Metabolism—Not Genomics—Be the Key?

    With: Thomas N. Seyfried, PhDDerek Lee, MSTomás Duraj, MD, PhD

    In 2018, we published a Curious Dr. George post featuring Thomas N. Seyfried, PhD, about cancer possibly being mostly a metabolic—rather than genetic—disease. Since then, the field of cancer genomics has expanded enormously, and we have published many posts in support of better understanding and treatment of many types of cancer based on the genomic approach. Here, Dr. Seyfried and two of his colleagues at Boston College—Derek Lee, MS,… Read more »