Why Does Exercise Guard Against Cancer? Inflammation May Play a RoleBookmark

Excerpt from The New York Times:

“One of the most important benefits of exercise is in how it reduces our risk of developing a number of types of cancer — especially colorectal cancer, which according to some estimates is the malignancy most influenced by physical activity. But how workouts guard against colon cancer remains largely unknown. Physical activity speeds the movement of waste through the intestines, as anyone who has had to hunt for a bathroom during a workout knows. But this does not seem to fully account for the protective effects of exercise. Instead, a small study published in February in The Journal of Physiology suggests we should also look to changes in our bloodstream after exercise.”

Go to full article published by The New York Times on April 22, 2019.

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Personalizing Precision Medicine with Combination Therapies Improves Outcomes in CancerBookmark

Excerpt:

“Precision oncology often relies on treating patients with a single, molecularly matched therapy that targets one mutation in their tumor. In a report, published online in Nature Medicine  on April 22, 2019, University of California San Diego School of Medicine researchers found that treating patients with personalized, combination therapies improved outcomes in patients with therapy resistant cancers.”

Go to full article published by UC San Diego Health on April 22, 2019.

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Regional Delivery of Mesothelin-Targeted CAR T-Cell Therapy Creates a Win for Solid TumorsBookmark

Excerpt:

“In patients with malignant pleural disease, autologous mesothelin-targeted chimeric antigen receptor (CAR) T-cell therapy demonstrated clinical benefit with no significant toxicity, outcomes that may be due to the regional delivery of the CAR T cells to the intrapleural cavity rather than conventional systemic delivery. The phase I trial (ClinicalTrials.gov identifier: NCT02414269) results were presented at the 2019 American Association for Cancer Research (AACR) Annual Meeting, held March 29–April 3 in Atlanta, Georgia (abstract CT036).”

Go to full article published by Cancer Network on April 10, 2019.

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FDA Expands Pembrolizumab Indication for First-Line Treatment of NSCLC (Tps ≥1%)Bookmark

Excerpt:

“On April 11, 2019, the Food and Drug Administration approved pembrolizumab (KEYTRUDA, Merck Inc.) for the first-line treatment of patients with stage III non-small cell lung cancer (NSCLC) who are not candidates for surgical resection or definitive chemoradiation or metastatic NSCLC. Patients’ tumors must have no EGFR or ALK genomic aberrations and express PD-L1 (Tumor Proportion Score [TPS] ≥1%) determined by an FDA-approved test.

“Pembrolizumab was previously approved as a single agent for the first-line treatment of patients with metastatic NSCLC whose tumors express PD-L1 TPS ≥50%.”

Go to full article published by the U.S. Food and Drug Administration on April 11, 2019.

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Pembrolizumab Shows Durable Benefit as Third-Line Treatment of Advanced Small Cell Lung CancerBookmark

Excerpt:

“Pembrolizumab demonstrated antitumor activity and induced durable responses in patients with advanced small cell lung cancer who had received two or more previous lines of therapy, according to pooled data from two KEYNOTE trials presented at American Association for Cancer Research Annual Meeting.”

Go to full article published by Healio on April 3, 2019

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