Marcus W. Bosenberg is Associate Professor of Dermatology and Pathology at Yale University. He completed medical and graduate education at Cornell University and clinical training in pathology and dermatopathology at Harvard Medical School. Dr. Bosenberg’s research interests are focused on the genetics and cell biology of melanoma progression and metastasis. He has developed a series of conditional inducible mouse models of melanoma that have clarified the synergistic effects of particular genetic changes in human melanoma. These models are also being utilized to study the sequential steps required for clinically evident metastasis and how the immune system can be stimulated to produce effective anti-tumor responses. Using these models, he has defined a distinct melanoma cell subset that is uniformly capable of forming tumors following injection of single purified cells and from cells that only rarely form tumors. He is interested in studying how cancer cell heterogeneity is maintained and how heterogeneity affects responses to therapeutic intervention. He is also attempting to identify novel combination therapies that are effective in particular genetic or phenotypic subsets of melanoma.
