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    New Treatments for Gastrointestinal Neuroendocrine Tumors

    Emma Shtivelman, PhD

    Neuroendocrine tumors (NETs) of the digestive system (GI-NETs) can arise in different parts of the digestive tract…Two new treatments for GI-NETs recently received much attention at the 2016 Gastrointestinal Cancers Symposium held in San Francisco in January. Researchers at the symposium presented clinical trial results that demonstrated the benefits of these new drugs.

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    Hormone-Mimicking Drugs Are Used To Treat Gastroenteropancreatic Neuroendocrine Tumors (GEP-NETs)

    Emma Shtivelman, PhD

    Neuroendocrine tumors (NETs) can arise wherever neuroendocrine (hormone-producing) cells are found—which is in most organs. Most NETs (65%-70%) are gastroenteropancreatic, or GEP, arising in different gastrointestinal organs. GEP-NETs are most commonly found in the small bowel (including the appendix), stomach, and rectum. Still, NETs in general are rare, which complicates the development of new treatments and identification of the genetic drivers of these cancers. Treatment of GEP-NETs is clearly an unmet medical need, and is now even more urgent because their incidence has been on the rise in the last 20 years.