Keytruda

  • July 26, 2024  

    How an Expert Would Treat His Own Advanced Lung Cancer: An Update

    With: Jack West, MD

    A new cancer diagnosis is overwhelming. Patients often ask their doctors, “What would you do if you were me?” Here, our Curious Dr. George asks lung cancer expert Howard (Jack) West, MD, FASCO, how he would handle his own diagnosis of advanced lung cancer. Dr. West is a Princeton- and Harvard-educated oncologist with additional training and experience in Boston and Seattle focusing on lung… Read more »

  • September 6, 2022  

    ‘Clinically Meaningful’ Improvement in SCLC Patients With Pembrolizumab/Chemo Combo Bookmark

    George Lundberg, MD

    As reported by MedPage Today, long-term results from a clinical trial suggest that a combination of the drug pembrolizumab plus chemotherapy is better than chemo alone for small cell lung cancer (SCLC). But unfortunately, most patients who received the combo did not benefit significantly, and biomarkers are very much needed to identify patients whose cancers will respond well.

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  • March 8, 2022  

    New Clinical Trial Results for Pembrolizumab in Triple-Negative Breast Cancer Bookmark

    George Lundberg, MD

    As reported in the medical research journal The Lancet, adding the drug pembrolizimab (Keytruda) to chemotherapy increased progression-free survival—both clinically and statistically—for clinical trial participants with advanced breast cancer.

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  • July 14, 2021  

    What’s New in Melanoma Treatment in 2021?

    Emma Shtivelman, PhD

    I last wrote about melanoma treatment more than 2 years ago, a fairly long time in the evolution of treatments for this type of cancer. Just as a refresher, the current mainstays of drugs to treat melanoma fall into two categories: Now, I highlight new developments in melanoma treatment, including overcoming resistance to ICI. Neoadjuvant (before surgery) treatments for resectable melanoma Some stage III… Read more »

  • April 28, 2021  

    How Can Detection of Tumor DNA in the Blood Aid Advanced Cancer Treatment?

    With: Alexey Aleshin, MD, MBAPaul Billings, MD, PhD

    As a tumor grows, it may shed fragments of its DNA into the patient’s bloodstream. After treatment, if part of the tumor remains or it begins to grow again, more of this circulating tumor DNA (ctDNA) may enter the blood. That raises the possibility that detecting ctDNA could help clinicians monitor molecular or minimal residual disease—cancer that remains after treatment and cannot be detected… Read more »

  • April 12, 2021  

    Lenvatinib/Pembrolizumab Improves Survival in Advanced Endometrial Cancer Bookmark

    George Lundberg, MD

    The ASCO Post reports on new results from a clinical trial testing a combination of the drugs lenvatinib and pembrolizumab in people with advanced or recurrent endometrial cancer. The results show that, compared to standard chemotherapy, this drug combo improves both overall and progression-free survival—according to both statistical and clinical analysis.

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  • March 9, 2021  

    How an Expert Would Treat His Own Advanced Lung Cancer

    With: Jack West, MD

    A new cancer diagnosis is overwhelming. Patients often ask their doctors, “What would you do if you were me?” Here, our Curious Dr. George asks lung cancer expert Howard (Jack) West, MD, how he would handle his own diagnosis of advanced lung cancer. Dr. West is a Princeton- and Harvard-educated oncologist with additional training and experience in Boston and Seattle focusing on lung cancer.… Read more »

  • November 24, 2020  

    Cancer Vaccine UV1 Plus Keytruda Shows Safety, Early Efficacy in Advanced Melanoma Trial Bookmark

    George Lundberg, MD

    A story from Immuno-Oncology News covers new results from a phase 1 clinical trial that indicate promising safety and early efficacy of a treatment that combines the drug Keytruda and an experimental cancer vaccine for people with advanced melanoma.

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  • August 15, 2020  

    Pembrolizumab Provides Long-Term Benefit in Melanoma, Regardless of BRAF+ Status or Prior Targeted Therapy Bookmark

    George Lundberg, MD

    Article from OncLive curated by Editor in Chief George Lundberg, MD, who notes: 

    A new study shows that the drug pembrolizomab significantly prolongs survival in patients with metastatic melanoma, regardless of whether their tumors have mutations in the BRAF gene or if they’ve had prior treatment with targeted therapy.

    Go to full article published by OncLive.

    If you’re wondering whether this story applies to your own cancer case or a loved one’s, we invite you to get support from Cancer Commons.

  • August 7, 2020  

    FDA Approves Merck’s Keytruda, Foundation Medicine CDx for TMB-High Solid Tumors Bookmark

    George Lundberg, MD

    Article from GenomeWeb curated by Editor in Chief George Lundberg, MD, who notes: 

    The U.S. Food and Drug Administration (FDA) has approved the drug pembrolizumab (brand name Keytruda) for solid tumors based solely on whether they have a high tumor mutational burden—a high number of changes in the DNA of the cancer cells.

    Go to full article published by GenomeWeb.

    If you’re wondering whether this story applies to your own cancer case or a loved one’s, we invite you to get support from Cancer Commons.