MEK inhibitors

  • July 14, 2021  

    What’s New in Melanoma Treatment in 2021?

    Emma Shtivelman, PhD

    I last wrote about melanoma treatment more than 2 years ago, a fairly long time in the evolution of treatments for this type of cancer. Just as a refresher, the current mainstays of drugs to treat melanoma fall into two categories: Now, I highlight new developments in melanoma treatment, including overcoming resistance to ICI. Neoadjuvant (before surgery) treatments for resectable melanoma Some stage III… Read more »

  • September 18, 2018  

    Overall Survival Improved With Encorafenib/Binimetinib Combination in BRAF-Mutant Melanoma Bookmark

    Emma Shtivelman, PhD

    Excerpt from The ASCO Post:

    “In patients with advanced BRAF V600–mutant melanoma, combining the BRAF inhibitor encorafenib (Braftovi) with the MEK inhibitor binimetinib (Mektovi) improved overall survival compared to vemurafenib (Zelboraf) or encorafenib as monotherapy, with a favorable toxicity profile, according to updated results from the phase III COLUMBUS trial.

    “Combined BRAF/MEK inhibitor therapy is standard of care in advanced BRAF V600–mutant melanoma, but approved combinations have unique toxicities that may impact the ability to deliver optimal treatment (ie, vemurafenib/cobimetinib [Cotellic] is associated with photosensitivity).”

    Go to full article published by The ASCO Post on Sep 10, 2018.

    If you’re wondering whether this story applies to your own cancer case or a loved one’s, we invite you to get support from Cancer Commons.