triple-negative

  • August 6, 2024  

    How an Expert Would Manage His Wife’s Metastatic Breast Cancer: An Update

    With: Richard B. Schwab, MD

    For most people with breast cancer, a lump is the first sign that leads to diagnosis. But some cases are not detected until after spread has already occurred. Here, our Curious Dr. George asks Richard B. Schwab, MD, how he would approach such a case if his own wife were the patient. Dr. Schwab is Senior Medical Director at Genentech Product Development Oncology. (Note:… Read more »

  • April 6, 2022  

    Essential Breast Cancer Treatment Trends in 2022: Webinar Highlights

    Sarah Stanley

    Women with breast cancer often face an overwhelming amount of information to sort through and decisions to make. Whether newly diagnosed or starting a next step in treatment, they may wonder: What does the latest research say about my type of breast cancer? Should I enroll in a clinical trial? How do I know if I’m receiving my best-possible treatment? Every day, Cancer Commons… Read more »

  • March 8, 2022  

    New Clinical Trial Results for Pembrolizumab in Triple-Negative Breast Cancer Bookmark

    George Lundberg, MD

    As reported in the medical research journal The Lancet, adding the drug pembrolizimab (Keytruda) to chemotherapy increased progression-free survival—both clinically and statistically—for clinical trial participants with advanced breast cancer.

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  • October 20, 2021  

    How an Expert Would Manage His Wife’s Metastatic Breast Cancer

    With: Richard B. Schwab, MD

    For most people with breast cancer, a lump is the first sign that leads to diagnosis. But some cases are not detected until after spread has already occurred. Here, our Curious Dr. George asks Richard B. Schwab, MD, how he would approach such a case if his own wife were the patient. Dr. Schwab is Professor of Medicine in the Division of Hematology/Oncology and… Read more »

  • April 12, 2021  

    FDA Grants Full Approval to Sacituzumab Govitecan for Triple-Negative Breast Cancer Bookmark

    George Lundberg, MD

    Recurrent triple-negative breast cancer is particularly difficult to treat. As reported by Cancer Network, the U.S. Food and Drug Administration (FDA) has now approved the drug sacituzumab govitecan (Trodelvy) for treating people with this disease, depending on their stage and treatment history.

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  • April 8, 2019  

    Atezolizumab/Nab-Paclitaxel Approved by the FDA for PD-L1+ TNBC Bookmark

    Emma Shtivelman, PhD

    Excerpt:

    “An accelerated approval has been granted by the FDA for the combination of atezolizumab (Tecentriq) and nab-paclitaxel (Abraxane) as a frontline treatment for patients with unresectable locally advanced or metastatic PD-L1–positive triple-negative breast cancer (TNBC).

    “The approval is based on the phase III IMpassion130 trial, in which the addition of the PD-L1 inhibitor atezolizumab to nab-paclitaxel reduced the risk of progression or death by 40% compared with nab-paclitaxel alone in this patient population.”

    Go to full article published by Targeted Oncology on March 8, 2019.

    If you’re wondering whether this story applies to your own cancer case or a loved one’s, we invite you to get support from Cancer Commons.

  • March 7, 2019  

    Experimental Drug Helps Women With Deadly Type of Breast Cancer Bookmark

    Emma Shtivelman, PhD

    Excerpt:

    “An experimental drug has shown promise in extending the lives of women suffering from a particularly aggressive and deadly type of breast cancer, according to the results of a phase 2 trial.

    “Right now, the standard treatment of chemotherapy for metastatic triple-negative breast cancer has not been very effective. That might change with the new drug, called sacituzumab govitecan, which combines an antibody with a chemotherapy drug to better target cancer cells.”

    Go to full article published by U.S. News on Feb 20, 2019.

    If you’re wondering whether this story applies to your own cancer case or a loved one’s, we invite you to get support from Cancer Commons.

  • October 22, 2018  

    Biomarker Selects TNBC Patients for Targeted Therapy Bookmark

    Emma Shtivelman, PhD

    Excerpt from MedPage Today:

    “A tumor necrosis-based gene expression signature (GS) successfully identified patients with triple-negative breast cancer (TNBC) responsive to neoadjuvant therapy with the novel targeted agent LCL161, according to researchers.

    “The international, randomized phase II trial of 207 patients with localized TNBC showed that of the 30.1% with GS-positive disease, a significantly higher pathologic complete response (pCR) was seen in those treated with paclitaxel plus the inhibitor of apoptosis antagonist LCL161 compared with those treated with paclitaxel alone (38.2% versus 17.2%).”

    Go to full article published by MedPage Today on Oct 5, 2018.

    If you’re wondering whether this story applies to your own cancer case or a loved one’s, we invite you to get support from Cancer Commons.

  • September 18, 2018  

    Biomarkers, PARP Inhibitors Vital for Personalized Treatment in Breast Cancer Subtypes Bookmark

    Emma Shtivelman, PhD

    Excerpt from OncLive:

    “Developing predictive biomarkers will be key to treating patients with triple-negative breast cancer (TNBC), especially when choosing a targeted therapy, said Banu K. Arun, MD.

    “In a presentation during the 2018 OncLive® State of the Science Summit™ on Breast Cancer, Arun said there is evidence that PARP inhibitors as well as immunotherapy in combination with various agents may be effective in women with TNBC and BRCA1-related breast cancers, but the science isn’t there yet.”

    Go to full article published by OncLive on Aug 29, 2018.

    If you’re wondering whether this story applies to your own cancer case or a loved one’s, we invite you to get support from Cancer Commons.

  • August 5, 2018  

    Atezolizumab Plus Chemotherapy Improves PFS for Triple-Negative Breast Cancer Bookmark

    Emma Shtivelman, PhD

    Excerpt from Healio:

    “First-line atezolizumab plus nab-paclitaxel improved PFS compared with placebo among patients with metastatic or unresectable locally advanced triple-negative breast cancer, according to interim results from the IMpassion130 trial released by the manufacturer.

    “Researchers observed prolonged PFS in both the intention-to-treat population and the PD-L1-positive population.”

    Go to full article published by Healio on July 2, 2018.

    If you’re wondering whether this story applies to your own cancer case or a loved one’s, we invite you to get support from Cancer Commons.