tumor mutation burden

  • October 11, 2022  

    Demystifying Cancer Biomarkers: Webinar Recap

    Sarah Stanley

    If you have just been diagnosed with cancer, or are facing recurrence, progression, or a change in treatment, you may feel bombarded with new information and advice. At some point, a clinician or even a well-meaning friend may urge you to have “biomarker testing” done. This phrase can be especially confusing when dealing with the stress of trying to understand a new diagnosis, a… Read more »

  • August 7, 2020  

    FDA Approves Merck’s Keytruda, Foundation Medicine CDx for TMB-High Solid Tumors Bookmark

    George Lundberg, MD

    Article from GenomeWeb curated by Editor in Chief George Lundberg, MD, who notes: 

    The U.S. Food and Drug Administration (FDA) has approved the drug pembrolizumab (brand name Keytruda) for solid tumors based solely on whether they have a high tumor mutational burden—a high number of changes in the DNA of the cancer cells.

    Go to full article published by GenomeWeb.

    If you’re wondering whether this story applies to your own cancer case or a loved one’s, we invite you to get support from Cancer Commons.

  • August 22, 2018  

    Study Describes Design, Validation of Foundation Medicine’s Blood-Based TMB Test Bookmark

    Emma Shtivelman, PhD

    Excerpt from GenomeWeb:

    “Researchers from Genentech, Foundation Medicine, UC Davis, and other medical centers, have published a report on the development and early validation of Foundation’s planned blood-based tumor mutational burden test.

    “Appearing today in Nature Medicine, the study describes the development of the test and its characteristics, and its retrospective validation in two cohorts. Investigators demonstrated, by applying the assay to samples from two clinical trials, that blood-based TMB (bTMB) could reproducibly identify lung cancer patients who respond to immunotherapy treatment with Roche/Genentech’s atezolizumab (Tecentriq).”

    Go to full article published by GenomeWeb on Aug 4, 2018 (Free registration required).

    If you’re wondering whether this story applies to your own cancer case or a loved one’s, we invite you to get support from Cancer Commons.